[ Title ]
- Assessment of DNA Integrity, Applications for Cancer Research
[ Journal ]
- ADVANCES IN CLINICAL CHEMISTRY
[ Author ]
- Zonta, E
Nizard, P
Taly, V
[ Abstract ]
- Many methods have been developed for DNA integrity assessment including
electrophoresis-based procedures, quantitative PCR, and, more recently,
microfluidics-based procedures. DNA integrity evaluation can be employed
for characterizing biological samples quality before extensive genomic
analysis and also finds applications in reproductive medicine, prenatal
diagnostics, or cancer research. In this chapter, we will focus on the
assessment of DNA integrity in cancer research. In particular, we will
present the application of the determination of DNA integrity for
tracking of circulating tumor DNA. Finally, we will conclude by
illustrating the potential innovative application of DNA integrity as a
biomarker in clinical research, especially for prognostic purposes,
patient follow-up, or early diagnosis.
[ URL ]
- http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord;UT=WOS:000363328700006