[ Title ]
- What is the role and impact of molecular markers on treatment decisions for colorectal cancer in the adjuvant setting?
[ Author ]
- H. M. Al-Salama, E. C. Johnstone and D. J. Kerr
[ Abstract ]
- The new mantra for delivering optimal cancer treatment is "personalized care." This extends beyond the holistic to using germline and somatic tumoral mutations to link a specific therapy to some prognostic or predictive factor which defines a particularly responsive patient subgroup who might benefit most from treatment. Furthermore, inherited polymorphisms have the potential to greatly modulate the side effects of treatment, especially for chemotherapy which has a notoriously narrow therapeutic window.
[ URL ]
- http://www.ncbi.nlm.nih.gov/pubmed/19833054